Genes linked to homosexuality have been discovered by scientists in the biggest ever study into the genetic basis for sexual orientation. For the first time, researchers looked at the complete genome - a person’s entire DNA code - for more than 1,000 gay men and compared it to genetic data from a similar number of heterosexual males. They discovered that DNA was different for gay and straight men around the genes SLITRK5 and SLITRK6. SLITRK6 is an important gene for brain development, and is particularly active in a region of the brain which includes the hypothalamus. The hypothalamus is crucial for producing the hormones which control sex drive, and previous studies have shown parts of it are up to 34 per cent larger in gay men. The researchers, from North Shore University Health System’s Research Institute, in Illinois, US, also discovered differences in the TSHR gene, which is linked to the thyroid, another area which has previously been associated with sexual orientation. “Because sexuality is an essential part of human life – for individuals and society – it is important to understand the development and expression of human sexual orientation,” said lead author Dr Alan Sanders. “The goal of this study was to search for genetic underpinnings of male sexual orientation, and thus ultimately increase our knowledge of biological mechanisms underlying sexual orientation. “What we have accomplished is a first step for genome wide study on the trait, and we hope that subsequent larger studies will further illuminate its genetic contributions.” The genes were linked to regions of the brain previously linked to sexuality, and the thyroid Participants in the study were rated for sexual orientation based on their self-reported sexual identity and sexual feelings. Men were asked to provide DNA by blood or saliva samples that were then genotyped and analysed. Although previous studies have pointed to a genetic predisposition for homosexuality, it is the first time researchers have studied the entire genome of individuals and so is the most comprehensive assessment of the genetic basis of sexuality ever undertaken. However British experts said more work was needed before it was possible to identify ‘gay genes’ because the genetic differences could point to other traits shared by the homosexual respondents. For example the variations may simply predispose people to be more open or candid about their lives. British experts warned that the gene differences may simply be linked to social traits, such as being more open, and more willing to take part in a survey about their sexual orientation Credit: Andrew Fox Prof Robin Lovell-Badge, Group Leader at The Francis Crick Institute, said: “The topic of this paper is important if we are to learn more about the influence of genes on aspects of our behaviour, but this is one that is notoriously difficult to study. “Even if a gene variant does show some correlation with sexual orientation, this does not mean that the gene is in any way responsible for being gay – it just means it has some association with a trait that is more likely to found in the relatively few people involved as subjects in the study. “This could be better social awareness or being brave enough to acknowledge that they are in a minority.” Gil McVean, Professor of Statistical Genetics at the University of Oxford, also added: “Sexuality is likely influenced by many different factors, including environment, experience and, likely, some aspects of innate biological variation. “I can see no major implications of this work or how it could be useful in the future. “The genetic effects are far too weak to be of any predictive or diagnostic value. All biology – including the origins of sexuality – is interesting at some level, but I see no direct applications of such research.” The research was published in the journal Scientific Reports.
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